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Which symptom is NOT associated with Cushing's disease or syndrome?

  1. Obesity

  2. Deep folliculitis

  3. High blood pressure

  4. Skin changes

The correct answer is: Deep folliculitis

Deep folliculitis is not typically associated with Cushing's disease or syndrome. Cushing's disease, resulting from prolonged exposure to high cortisol levels, manifests through various symptoms related to metabolic dysregulation, such as obesity, high blood pressure, and noticeable skin changes. Obesity occurs due to the effects of cortisol on fat distribution, leading to the characteristic "moon face" and central adiposity. High blood pressure is another common symptom because elevated cortisol levels can increase blood volume and sensitivity to adrenaline. Skin changes, such as easy bruising, striae, and thinning of the skin, also occur due to the impact of excess cortisol on collagen and skin integrity. In contrast, while folliculitis involves inflammation or infection of hair follicles and can be related to various factors such as bacteria or irritants, it is not a recognized symptom of Cushing's disease or syndrome, making it the correct choice as the symptom that is NOT typically associated with this condition.